Hormone Suppressants for Cancer Treatment

Abiraterone

Brand/Trade Names: Zytiga

Manufacturer: ALP Pharm Beijing Co.,  Acebright India Pharma Private Limited, Aspen Biopharma Labs Pvt,   Aspire Lifesciences Pvt,   Aurisco Pharmaceutical Co.

Formula: C24H31NO

Mechanism:  Anti-Androgen, CYP17A1 inhibitor

Class: Hormone Suppressant

Administration: Oral

Notes:  Approved by the FDA in 2011.  Used for treatment of prostate cancer.

Apalutamide

Brand/Trade Names: Erleada

Manufacturer: Janssen Pharmaceuticals 

Formula: C21H15F4N5O2S

Mechanism: Anti-Androgen

Class: Hormone Suppressant

Administration: Oral

Notes:  Approved by the FDA in 2018.  Used for treatment of prostate cancer.

Bicalutamide

Brand/Trade Names: Casodex

Manufacturers: ANI Pharmaceuticals Aarti Industries Ltd,   Apotex Pharmachem Inc.,   Arevipharma GmbH,   Aspen Biopharma Labs Pvt

Formula: C18H14F4N2O4S

Mechanism: Anti-Androgen

Class: Hormone Suppressant

Administration: Oral

Notes: Approved by the FDA in 1995.  Used for treatment of prostate cancer.

Darolutamide

Brand/Trade Names: Nubeqa

Manufacturer: Bayer HealthCare Pharmaceuticals

Formula: C19H19ClN6O2

Mechanism: Anti-Androgen

Class: Hormone Suppressant

Administration: Oral

Notes: Approved by the FDA in 2019.  Used in treatment of prostate cancer.

Degarelix

Brand/Trade Names: Firmagon

Manufacturers: Ferring Pharmaceuticals, Auro Peptides Limited, Bachem AG  Hemmo Pharmaceuticals Private Limited  Omgene Life Sciences

Formula: C84H107ClN18O18

Mechanism: Gonadotropin-releasing hormone antagonist

Class: Hormone Suppressant

Administration: Oral

Notes: Approved by the FDA in 2008.  Used for treatment of prostate cancer.

Estramustine

Brand/Trade Names: Emcyt

Manufacturers: 

Formula: C23H31Cl2NO3

Mechanism: Estrogen agonist

Class: Hormone analog

Administration: Oral

Notes: Estrogen ester, conjugated with estradiol, used for advanced prostate cancer.  Approved by the FDA in 1981.

Enzalutamide

Brand/Trade Names: Xtandi

Manufacturers: Astellas Pharma US Inc, Acebright India Pharma Private Limited, Actavis Inc., Aurisco Pharmaceutical Co.,   Catalent Pharma Solutions

Formula: C21H16F4N4O2S

Mechanism: Anti-Androgen

Class: Hormone Suppressant

Administration: Oral

Notes:  Approved by the FDA in 2012.   Used for treatment of prostate cancer.

Goserelin

Brand/Trade Names: Zoladex

Manufacturers: TerSera Therapeutics, ALP Pharm Beijing Co., AmbioPharm. Aspen API, AstraZeneca

Formula: C59H84N18O14

Mechanism: Gonadotropin-releasing hormone antagonist (GnRH antagonist)

Class:  Hormone Suppressant

Administration: Subcutaneous (injection under skin)

Notes: Approved by the FDA in 1989.  Used for treatment of breast and prostate cancer.

Leuprolide

Brand/Trade Names: Viadur, Eligard

Manufacturers: Tolmar Pharmaceuticals, ALP Pharm Beijing Co., Ltd, Anhui Anke Biotechnology Co,   Anygen Co Ltd, AmbioPharm

Formula: C59H84N16O12

Mechanism: Gonadotropin-releasing hormone antagonist

Class: Hormone Suppressant/

Administration: Subcutaneous (injection under skin)

Notes:  Approved by the FDA in 1985.  Used in treatment of prostate, breast, ovarian, and uterine cancer.

Mitotane

Brand/Trade Names: Lysodren

Formula: C14H10Cl4

Manufacturers: TNTERNATIONAL SPECIALTY PRODUCTS, ISP Chemicals, PCI Synthesis, Tecoland Corporation

Mechanism: inhibitor of the adrenal cortex

Class: Hormone Suppressant

Administration: Oral, three or four divided doses per day.

Notes:  Approved by the FDA in 1970.  Used in treatment of adrenocortical carcinoma.

Nilutamide

Brand/Trade Names: Nilandron, Anandron

Manufacturers: Concordia  Pharmaceuticals, Biophore India Pharmaceuticals Pvt Ltd. ChemGenix Laboratories Pvt Ltd, Kekule Pharma Limited, Sionc Pharmaceuticals

Formula: C12H10F3N3O4

Mechanism: Anti-Androgen

Class: Hormone SuppreFLssant

Administration: Oral

Notes:  Approved by the FDA in 1996.  Used in treatment of prostate cancer.

Megestrol

Brand/Trade Names: Megace

Manufacturers: Pharmacia & Upjohn Company, Bayer HealthCare, Farmabios SPA, Fujifilm Diosynth Biotechnologies  Jiangsu Grand XianleI Pharmaceutical Co.  

Formula: C24H32O4

Mechanism: Inhibitor of the adrenal cortex

Class: Hormone Influencer

Administration: Oral

Notes:  Approved by the FDA in 1971.

Octreotide

Brand/Trade Names: Sandostatin

Manufacturers: Novartis Pharmaceuticals Corporation, Anhui Anke Biotechnology Co., LTD,   AmbioPharm, Auro Peptides Limited, ALP Pharm Beijing Co.

Formula: C49H66N10O10S2

Mechanism: Suppresses human growth hormone

Class: hormone (somatostatin) analog

Administration: Intravenous, subcutaneous

Notes:  Approved by the FDA in 1988.  Used for treatment of cancerous tumors that secrete growth hormone. Doesn’t directly attack cancer, but helps with side effects when other therapy attacks cancer.

Relugolix

Brand/Trade Names: Orgovyx

Manufacturers: Myovant Sciences GmbH

Formula: C29H27F2N7O5S

Mechanism:  Gonadotropin releasing hormone antagonist

Class: hormone suppressant

Administration: Oral

Notes:  Approved by the FDA in 2020.  Used for treatment of prostate cancer.

Toremifene

Brand/Trade Names: Fareston

Manufacturers: Kyowa Kirin. Asymchem Laboratories, Chongqing Fuan Pharmaceutical,  Fermion Oy,   MSN Laboratories Pvt

Formula: C26H28ClNO

Mechanism: Selective estrogen receptor modulator (SERM)

Class: Hormone suppressant (anti-estrogen)

Administration: Oral

Notes:  Approved by the FDA in 1997.  Used for treatment of breast cancer.

Triptorelin

Brand/Trade Names: Decapeptyl, Gonapeptyl, Trelstar

Manufacturers: Allergan, AmbioPharm, BCN Peptides SA, Bachem AG, Debiopharm  

Formula: C64H82N18O13

Mechanism: Gonadotropin-releasing hormone agonist

Class: Hormone Suppressant

Administration: Intravenous

Notes:  Approved by the FDA in 2017.  Used in treatment of prostate cancer.

Fulvestrant

Brand/Trade Names: Faslodex

Manufacturers: AstraZeneca Pharmaceuticals LP, ChemWerth, Farmabios SPA. Gland Pharma Limited

Formula: C32H47F5O3S

Mechanism: Anti-estrogen

Class: Hormone Suppressant

Administration: Injection to muscle

Notes:  Approved by the FDA in 2002.  Used in treatment of breast cancer.

Histrelin

Brand/Trade Names: Vantas, Supprelin LA

Manufacturers: Endo Pharmaceuticals, Bachem AG, Shenzhen, JYMed Technology 

Formula: C66H86N18O12

Mechanism: Gonadotropin-releasing hormone agonist 

Class: Hormone Suppressant

Administration: intramuscular injection, subcutaneous implant

Notes:  Approved by the FDA in 2004.

Flutamide

Brand/Trade Names: Eulexin

Manufacturers: MSD International GmbH, AMRI, Arevipharma GmbH, Coral Drugs Private Limited, Cipla

Formula: C11H11F3N2O3

Mechanism: Anti-androgen

Class: Hormone Suppressant

Administration: Oral

Notes:  Approved by the FDA in 1989.  Used for treatment of prostate cancer.

Tamoxifen

Brand/Trade Names: Nolvadex, Istubal, and Valodex 

Manufacturer: AstraZeneca

Formula: C26H29NO

Mechanism: Anti-Estrogen, Selective estrogen receptor modulator

Class:  Hormone Suppressant

Administration: Oral

Notes: Approved by the FDA in 1979.  Used in treatment of breast cancer.

PDF of hormone influencers