Hormone Suppressants for Cancer Treatment
Abiraterone
Brand/Trade Names: Zytiga
Manufacturer: ALP Pharm Beijing Co., Acebright India Pharma Private Limited, Aspen Biopharma Labs Pvt, Aspire Lifesciences Pvt, Aurisco Pharmaceutical Co.
Formula: C24H31NO
Mechanism: Anti-Androgen, CYP17A1 inhibitor
Class: Hormone Suppressant
Administration: Oral
Notes: Approved by the FDA in 2011. Used for treatment of prostate cancer.
Apalutamide
Brand/Trade Names: Erleada
Manufacturer: Janssen Pharmaceuticals
Formula: C21H15F4N5O2S
Mechanism: Anti-Androgen
Class: Hormone Suppressant
Administration: Oral
Notes: Approved by the FDA in 2018. Used for treatment of prostate cancer.
Bicalutamide
Brand/Trade Names: Casodex
Manufacturers: ANI Pharmaceuticals Aarti Industries Ltd, Apotex Pharmachem Inc., Arevipharma GmbH, Aspen Biopharma Labs Pvt
Formula: C18H14F4N2O4S
Mechanism: Anti-Androgen
Class: Hormone Suppressant
Administration: Oral
Notes: Approved by the FDA in 1995. Used for treatment of prostate cancer.
Darolutamide
Brand/Trade Names: Nubeqa
Manufacturer: Bayer HealthCare Pharmaceuticals
Formula: C19H19ClN6O2
Mechanism: Anti-Androgen
Class: Hormone Suppressant
Administration: Oral
Notes: Approved by the FDA in 2019. Used in treatment of prostate cancer.
Degarelix
Brand/Trade Names: Firmagon
Manufacturers: Ferring Pharmaceuticals, Auro Peptides Limited, Bachem AG Hemmo Pharmaceuticals Private Limited Omgene Life Sciences
Formula: C84H107ClN18O18
Mechanism: Gonadotropin-releasing hormone antagonist
Class: Hormone Suppressant
Administration: Oral
Notes: Approved by the FDA in 2008. Used for treatment of prostate cancer.
Estramustine
Brand/Trade Names: Emcyt
Manufacturers:
Formula: C23H31Cl2NO3
Mechanism: Estrogen agonist
Class: Hormone analog
Administration: Oral
Notes: Estrogen ester, conjugated with estradiol, used for advanced prostate cancer. Approved by the FDA in 1981.
Enzalutamide
Brand/Trade Names: Xtandi
Manufacturers: Astellas Pharma US Inc, Acebright India Pharma Private Limited, Actavis Inc., Aurisco Pharmaceutical Co., Catalent Pharma Solutions
Formula: C21H16F4N4O2S
Mechanism: Anti-Androgen
Class: Hormone Suppressant
Administration: Oral
Notes: Approved by the FDA in 2012. Used for treatment of prostate cancer.
Goserelin
Brand/Trade Names: Zoladex
Manufacturers: TerSera Therapeutics, ALP Pharm Beijing Co., AmbioPharm. Aspen API, AstraZeneca
Formula: C59H84N18O14
Mechanism: Gonadotropin-releasing hormone antagonist (GnRH antagonist)
Class: Hormone Suppressant
Administration: Subcutaneous (injection under skin)
Notes: Approved by the FDA in 1989. Used for treatment of breast and prostate cancer.
Leuprolide
Brand/Trade Names: Viadur, Eligard
Manufacturers: Tolmar Pharmaceuticals, ALP Pharm Beijing Co., Ltd, Anhui Anke Biotechnology Co, Anygen Co Ltd, AmbioPharm
Formula: C59H84N16O12
Mechanism: Gonadotropin-releasing hormone antagonist
Class: Hormone Suppressant/
Administration: Subcutaneous (injection under skin)
Notes: Approved by the FDA in 1985. Used in treatment of prostate, breast, ovarian, and uterine cancer.
Mitotane
Brand/Trade Names: Lysodren
Formula: C14H10Cl4
Manufacturers: TNTERNATIONAL SPECIALTY PRODUCTS, ISP Chemicals, PCI Synthesis, Tecoland Corporation
Mechanism: inhibitor of the adrenal cortex
Class: Hormone Suppressant
Administration: Oral, three or four divided doses per day.
Notes: Approved by the FDA in 1970. Used in treatment of adrenocortical carcinoma.
Nilutamide
Brand/Trade Names: Nilandron, Anandron
Manufacturers: Concordia Pharmaceuticals, Biophore India Pharmaceuticals Pvt Ltd. ChemGenix Laboratories Pvt Ltd, Kekule Pharma Limited, Sionc Pharmaceuticals
Formula: C12H10F3N3O4
Mechanism: Anti-Androgen
Class: Hormone SuppreFLssant
Administration: Oral
Notes: Approved by the FDA in 1996. Used in treatment of prostate cancer.
Megestrol
Brand/Trade Names: Megace
Manufacturers: Pharmacia & Upjohn Company, Bayer HealthCare, Farmabios SPA, Fujifilm Diosynth Biotechnologies Jiangsu Grand XianleI Pharmaceutical Co.
Formula: C24H32O4
Mechanism: Inhibitor of the adrenal cortex
Class: Hormone Influencer
Administration: Oral
Notes: Approved by the FDA in 1971.
Octreotide
Brand/Trade Names: Sandostatin
Manufacturers: Novartis Pharmaceuticals Corporation, Anhui Anke Biotechnology Co., LTD, AmbioPharm, Auro Peptides Limited, ALP Pharm Beijing Co.
Formula: C49H66N10O10S2
Mechanism: Suppresses human growth hormone
Class: hormone (somatostatin) analog
Administration: Intravenous, subcutaneous
Notes: Approved by the FDA in 1988. Used for treatment of cancerous tumors that secrete growth hormone. Doesn’t directly attack cancer, but helps with side effects when other therapy attacks cancer.
Relugolix
Brand/Trade Names: Orgovyx
Manufacturers: Myovant Sciences GmbH
Formula: C29H27F2N7O5S
Mechanism: Gonadotropin releasing hormone antagonist
Class: hormone suppressant
Administration: Oral
Notes: Approved by the FDA in 2020. Used for treatment of prostate cancer.
Toremifene
Brand/Trade Names: Fareston
Manufacturers: Kyowa Kirin. Asymchem Laboratories, Chongqing Fuan Pharmaceutical, Fermion Oy, MSN Laboratories Pvt
Formula: C26H28ClNO
Mechanism: Selective estrogen receptor modulator (SERM)
Class: Hormone suppressant (anti-estrogen)
Administration: Oral
Notes: Approved by the FDA in 1997. Used for treatment of breast cancer.
Triptorelin
Brand/Trade Names: Decapeptyl, Gonapeptyl, Trelstar
Manufacturers: Allergan, AmbioPharm, BCN Peptides SA, Bachem AG, Debiopharm
Formula: C64H82N18O13
Mechanism: Gonadotropin-releasing hormone agonist
Class: Hormone Suppressant
Administration: Intravenous
Notes: Approved by the FDA in 2001. Used in treatment of prostate cancer.
Fulvestrant
Brand/Trade Names: Faslodex
Manufacturers: AstraZeneca Pharmaceuticals LP, ChemWerth, Farmabios SPA. Gland Pharma Limited
Formula: C32H47F5O3S
Mechanism: Anti-estrogen
Class: Hormone Suppressant
Administration: Injection to muscle
Notes: Approved by the FDA in 2002. Used in treatment of breast cancer.
Histrelin
Brand/Trade Names: Vantas, Supprelin LA
Manufacturers: Endo Pharmaceuticals, Bachem AG, Shenzhen, JYMed Technology
Formula: C66H86N18O12
Mechanism: Gonadotropin-releasing hormone agonist
Class: Hormone Suppressant
Administration: intramuscular injection, subcutaneous implant
Notes: Approved by the FDA in 2004.
Flutamide
Brand/Trade Names: Eulexin
Manufacturers: MSD International GmbH, AMRI, Arevipharma GmbH, Coral Drugs Private Limited, Cipla
Formula: C11H11F3N2O3
Mechanism: Anti-androgen
Class: Hormone Suppressant
Administration: Oral
Notes: Approved by the FDA in 1989. Used for treatment of prostate cancer.
Tamoxifen
Brand/Trade Names: Nolvadex, Istubal, and Valodex
Manufacturer: AstraZeneca
Formula: C26H29NO
Mechanism: Anti-Estrogen, Selective estrogen receptor modulator
Class: Hormone Suppressant
Administration: Oral
Notes: Approved by the FDA in 1979. Used in treatment of breast cancer.