Drug Target and Protein Substrates

Kinase inhibitors target:

Drug target Protein substrate
ALK Tyrosine
BCR–Abl Tyrosine
B-Raf Serine/threonine
BTK Tyrosine
CDK family Serine/threonine
c-Met Tyrosine
EGFR family Tyrosine
JAK family Tyrosine
MEK1/2 More than one
PDGFR α/β Tyrosine
RET Tyrosine
Src family Tyrosine
VEGFR family Tyrosine