Drug Target and Protein Substrates

Kinase inhibitors target:

Drug targetProtein substrate
ALKTyrosine
BCR–AblTyrosine
B-RafSerine/threonine
BTKTyrosine
CDK familySerine/threonine
c-MetTyrosine
EGFR familyTyrosine
JAK familyTyrosine
MEK1/2More than one
PDGFR α/βTyrosine
RETTyrosine
Src familyTyrosine
VEGFR familyTyrosine